METHADONE KITTY FOR DUMMIES

[sixty one] Like a lot of other cardiotoxic drugs, methadone blocks the hERG K+ channel. The 2 enantiomers of methadone inhibit hERG channels with distinctive potency. Dextromethadone, which is a lot less powerful as an opioid, is much more strong at blocking the hERG channel with an IC50 of ~12 μM. Levomethadone incorporates a lower affinity, wit